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Cardiológicos
PIMOCARD
description
Positive inotrope and peripheral vasodilator in tablets for oral administration.
presentation
Cases containing 2 blisters with 10 tablets each.
action
It increases the cardiac contraction force based on two mechanisms: 1) myocardial sensitization to the calcium effects.
2) inhibition of the phosphodiesterase-III enzyme.
It reduces vascular resistance generating vasodilation.
SECONDARY ACTIONS:
It prolongs the cardiac cell action potential and reduces the tendency to reentrant arrhythmias.
It avoids platelet aggregation and prevents thrombus formation.
It reduces catecholamines and, consequently, stress.
indications
Congestive heart failure class C in dogs due to valve insufficiency or dilated cardiomyopathy.
formula
Each tablet contains:
Pimobendan 1.25 mg/2.5 mg/5 mg and 10 mg depending on dosage form. Excipients q.s.
dosage and administration
Dogs: 0.2 and 0.6 mg of pimobendan a day per kg of body weight distributed in two administrations of 0.25 mg/kg each (equivalent to 1 tablet every 5 kg, 10 kg or 20 kg or 40 kg every 12 hours depending on the dosage form).
contraindications
It should not be administered in cases of hypertrophic cardiomyopathies or clinical conditions where increasing the cardiac output is not possible due to functional or anatomical conditions (e.g.: aortic stenosis). Given than pimobendan.It should not be administered in cases of hypertrophic cardiomyopathies or clinical conditions where increasing the cardiac output is not possible due to functional or anatomical conditions (e.g.: aortic stenosis). Given than pimobendan is metabolized in the liver, it should not be used in dogs with severe liver failure. Do not use in case of hypersensitivity to the main ingredient or any of the excipients.
collateral damage
Adverse gastrointestinal reactions, such as vomiting and diarrhea, have been rarely reported.
restrictions on use
Its use during pregnancy and lactation is recommended only if the therapeutic benefit outweighs the potential risk. Using it in puppies is not advisable.
Caution
The product absorption is modified when it is administered with food. Therefore, optimal efficacy is obtained on an empty stomach so it must be administered one hour before meals. In diabetic animals, glucose levels should be strictly controlled.