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Gastroenterológicos
PILERAN INJECTABLE
description
Solution for injection with gastrokinetic antiemetic effect.
presentation
50 mL vial.
action
Central antiemetic. The central antiemetic mechanism of action is a dopaminergic antagonism at the level of the chemoreceptor trigger zone. Peripherally, it is gastrokinetic and increases the gastrointestinal motility up to the colon with a gastric emptying action.
indications
Treatment of vomiting of various etiologies, reflux esophagitis, nausea and gastric motility disorders. Preparation for radiological tests of the GI tract.
formula
100 mL of the solution contains:
Metoclopramide hydrochloride 0.5 g
Excipients q.s.
dosage and administration
0.5 mg/kg of body weight/8 hours, equivalent to 1 mL of Pileran®/10 kg of body weight/8 hours. By continuous infusion: 1-2 mg/kg of body weight/day, equivalent to 1 mL of Pileran®/2.5 – 5 kg of body weight every/day.
contraindications
Do not use in gastrointestinal episodes associated with the presence of sharp foreign bodies, mechanical obstruction or digestive perforations. Contraindicated in animals with seizures and in animals medicated with neuroleptics. Do not use in patients with hypersensitivity to the main ingredient. Do not use in early stages of pregnancy or during lactation.
collateral damage
In rare occasions, there are effects associated with dopamine receptor blockade, characterized by behavioral changes, restlessness, disorientation, and hallucinations. A sedative effect occurs in some cases.
restrictions on use
Use with caution in patients with liver and renal failure and in epileptic patients.
Caution
In the administration by continuous infusion, protecting the parenteral solution where Metoclopramide is diluted from light is recommended. Use with caution in debilitated animals .